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Igor V Peshenko Selected Research

Calcium

10/2021Retinal degeneration-3 protein attenuates photoreceptor degeneration in transgenic mice expressing dominant mutation of human retinal guanylyl cyclase.
1/2021Regulation of retinal membrane guanylyl cyclase (RetGC) by negative calcium feedback and RD3 protein.
1/2020Two clusters of surface-exposed amino acid residues enable high-affinity binding of retinal degeneration-3 (RD3) protein to retinal guanylyl cyclase.
1/2019A G86R mutation in the calcium-sensor protein GCAP1 alters regulation of retinal guanylyl cyclase and causes dominant cone-rod degeneration.
1/2019Retinal guanylyl cyclase activation by calcium sensor proteins mediates photoreceptor degeneration in an rd3 mouse model of congenital human blindness.
1/2018GUCY2D Cone-Rod Dystrophy-6 Is a "Phototransduction Disease" Triggered by Abnormal Calcium Feedback on Retinal Membrane Guanylyl Cyclase 1.
11/2016The R838S Mutation in Retinal Guanylyl Cyclase 1 (RetGC1) Alters Calcium Sensitivity of cGMP Synthesis in the Retina and Causes Blindness in Transgenic Mice.
1/2012Enzymatic relay mechanism stimulates cyclic GMP synthesis in rod photoresponse: biochemical and physiological study in guanylyl cyclase activating protein 1 knockout mice.

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Igor V Peshenko Research Topics

Disease

10Blindness (Hysterical Blindness)
10/2022 - 08/2015
8Retinal Degeneration
10/2021 - 08/2007
6Leber Congenital Amaurosis
10/2022 - 02/2010
4Cone-Rod Dystrophies
12/2020 - 11/2016
2Retinal Dystrophies
01/2021 - 02/2010
2type 1 Amaurosis congenita of Leber
01/2016 - 01/2013
2Retinal Diseases
04/2014 - 01/2012
1Retinal cone dystrophy 2
10/2021
1Night Blindness (Nyctalopia)
12/2020
1congenital stationary Night blindness
12/2020
1Photophobia (Light Sensitivity)
01/2010
1Cataract (Cataracts)
10/2003
1Mitochondrial Diseases (Mitochondrial Disease)
10/2003

Drug/Important Bio-Agent (IBA)

18Retinaldehyde (Retinal)IBA
10/2021 - 08/2007
17Guanylate Cyclase (Guanylyl Cyclase)IBA
10/2021 - 08/2007
14Proteins (Proteins, Gene)FDA Link
10/2021 - 11/2011
8CalciumIBA
10/2021 - 01/2012
6Guanylate Cyclase-Activating ProteinsIBA
01/2020 - 01/2010
3IsoenzymesIBA
10/2021 - 01/2012
2EnzymesIBA
01/2016 - 04/2014
2Phosphotransferases (Kinase)IBA
03/2015 - 02/2010
1Cyclic GMPIBA
10/2022
1Staphylococcal Protein A (Protein A)IBA
01/2019
1Carrier Proteins (Binding Protein)IBA
11/2011
1calpain inhibitorsIBA
10/2003
1Acetaminophen (Paracetamol)FDA LinkGeneric
10/2003
1CalpainIBA
10/2003
1N-acetyl-4-benzoquinoneimine (NAPQI)IBA
10/2003
1Peptide Hydrolases (Proteases)FDA Link
10/2003

Therapy/Procedure

1Therapeutics
01/2013
1Intraperitoneal Injections
10/2003